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The epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid, from which it is produced by the enzyme epoxygenase. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects. EETs are metabolized by the soluble epoxide hydrolase to the corresponding vicinal diol, or dihydroxyeicosatrienoic acids (DHETs), which are biologically less active. ==Biological effects== Generally, EETs cause: *Calcium release from intracellular stores〔 *Increased sodium-hydrogen antiporter activity〔 *Increased cell proliferation〔 *Decreased cyclooxygenase activity〔 Other effects are specific to certain cells or locations: *EETs are cardioprotective after ischemic heart attack and reperfusion. *They act in the corpus cavernosum to maintain penile erection. *Specific epoxidation of EET sites produces endogenous PPARα agonists. *Decreased release of somatostatin, insulin and glucagon from endocrine cells.〔 *Vasodilation and angiogenesis in blood vessels.〔 *Increased risk of tumor adhesion on endothelial cells〔 *Decreased platelet aggregation〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Epoxyeicosatrienoic acid」の詳細全文を読む スポンサード リンク
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